papers

Personalized interpretation of medical reports has emerged as an increasingly important need among patients. Addressing this need requires both evidence-grounded medical factuality and context-dependent patient communication, yet existing medical vision-language tasks do not adequately capture these dual requirements. To bridge this gap, we introduce Patient-oriented Medical Report Interpretation (PMRI), a novel open-ended multimodal generation task that requires models to explain medical reports in accurate and accessible language based on a user's query and dialogue history. These two objectives differ fundamentally in their verifiability, yet remain tightly coupled, making them difficult to optimize jointly under conventional supervised fine-tuning and holistic reinforcement learning paradigms. To address this challenge, we propose G-CARL, a grounded, checklist-aligned reinforcement learning framework that combines multi-source retrieval for atomic claim verification with context-aware, instance-specific weighted checklists for response coverage, providing structured supervision for factuality, user-demand satisfaction, and expression quality without constraining response diversity. We further construct MMedReport, a real-world PMRI benchmark, along with a clinician-designed three-dimensional evaluation protocol. Extensive experiments demonstrate that G-CARL consistently outperforms existing post-training baselines in overall quality, claim-level precision, and checklist recall. Pairwise preference evaluation by clinicians further confirms that G-CARL produces interpretations that are more accurate and better aligned with patient needs.

Travel behavior research increasingly combines digital data collection with predictive modeling, yet these stages are often developed and evaluated separately. This study proposes a three-agent workflow integrating conversational data collection, structured data processing, and behavioral prediction. A chatbot-administered, image-augmented stated-preference survey collected mode choices from student commuters across five predefined weather scenarios, yielding 454 respondent-scenario observations. Weather-related associations were analyzed using a multinomial logit model, while logistic regression and random forest provided machine-learning benchmarks. Nine locally deployed large language models (LLMs), ranging from 2 to 35 billion parameters, were evaluated across four zero-shot prompt-and-context conditions and extended through persona, few-shot, and vision-based configurations. Random forest achieved 69.6% five-class accuracy, while the best text-only zero-shot LLM reached 69.9% without task-specific fitting. Habitual travel information produced the most consistent gains, Expert framing generally outperformed Role-Play, and persona information was most useful when habitual travel information was unavailable. Few-shot prompting improved prediction for several models, with gains stabilizing after a small number of examples. Using the same weather images shown to respondents, the best vision-based configuration reached 71.5% five-class accuracy, indicating that visual context may provide additional predictive information for selected models. Overall, the study shows how conversational surveys, structured data processing, conventional behavioral modeling, machine learning, and multimodal LLM prediction can be coordinated within an auditable multi-agent workflow.

Naturalistic computer-use traces, passively recorded screenshots and mouse or keyboard actions, are a valuable resource for deriving symbolic, auditable, and reusable models of how everyday work is done. Such models matter as computer-use agents enter real work, where agents need to learn how tasks are actually performed, and organizations need to audit and reuse that knowledge. However, inducing such task models is challenging, as activity is observed only as low-level events and real-world work is multi-threaded with interleaved goals. Existing methods assume a given task or a single workflow, and produce step-level summaries rather than structured task models. We introduce Task Model Induction (TMI), which (i) discovers the latent tasks in an unconstrained trace, disentangling concurrent activity, and (ii) for each latent task, induces a task model pairing a hierarchical objective model of recursive goal decomposition with a procedure model of the control flow that organized the execution. Intrinsically, on controlled human and agent trajectories, TMI recovers interleaved tasks with 0.974 agreement against ground-truth groupings and reconstructs 74.9% of the observed execution steps, far more than the strongest workflow induction baseline. Extrinsically, skills derived from TMI's task models improve held-out task accuracy by 30.0% over the strongest baseline.

Recursive self-improvement (RSI) asks whether an AI system can improve the process that produces AI systems, so that the next system inherits the improvement. That process is the training algorithm: a better objective or update rule improves the compute\mbox{-}capability exchange rate for every subsequent run, including the one that produces the next agent. Whether RSI is feasible therefore turns on whether an agent can design training algorithms. No benchmark isolates that ability: existing suites are won by collecting data or by tuning hyperparameters, and none tells a change to how a run is executed apart from a change to how the model learns. We present AI4AI\mbox{-}Bench, 10 frozen research repositories spanning 10 training algorithm families. In each task, an agent has 4 hours on one B300 to rewrite the training algorithm; its code is then rerun from scratch for up to 12 hours and scored by a fixed evaluator hidden from the agent, against the repository's original algorithm under the same procedure. Because the 10 metrics are incommensurable, every task is mapped onto one scale on which $0$ is an uninformative model, $0.1$ is the algorithm the repository ships, and $1.0$ is the task optimum. Across 29 configurations of 6 systems on all 10 tasks the mean score is $0.166$, and the best system reaches $0.250$: even the strongest closes under a fifth of the distance between the algorithm that was already there and the optimum. The submissions show where that distance went: most never change how the model learns at all, and the minority that do average $0.226$ against $0.126$ for the rest. More reasoning effort mostly buys the willingness to go there, taking that minority from $8\%$ of submissions to $64\%$ and the mean score from $0.094$ to $0.196$. We release the task suite, the evaluators and every scored submission, so that the measurement can be repeated as these systems change.

Heterogeneous AI systems composed of multiple models, architectures, harnesses, or inference-time settings can improve quality and efficiency by routing queries to the specialist who can answer most effectively at the lowest cost. Routing requires estimating each specialist's expected return, but this value estimation has a cost. Cheap estimators (e.g., embedding-based predictors) are fast but noisy, while accurate estimators (e.g., fine-tuned models with access to retrieval results or partial reasoning traces) are expensive. We formalize this tradeoff as an instance of Pandora's Box, the classical problem of optimal search with costly inspection. Under a Gaussian signal model, the resulting policies have closed-form value-of-information expressions that determine, for each specialist and input, whether refining the value estimate is worth its cost. We call the centralized policy Pandora's Router. We extend this to a decentralized setting, Pandora's Bidder, where specialists independently decide whether to invest in self-assessment before accepting an offered price to claim a query. Experiments across three domains---a standard multi-LLM benchmark, retrieval-augmented specialists, and LLMs with variable inference-time reasoning---show that Pandora's Router matches the routing quality of exhaustive estimation, while querying the expensive estimator far less often. In the decentralized setting, value-of-information reasoning improves allocative efficiency when competing estimates are accurate; when competing estimates are noisy, however, it can increase the strategic specialist's utility at the expense of others.

Mid-training is increasingly recognized as a critical stage for shaping the capabilities of large language models. Recent work has shown that targeted mid-training can strengthen reasoning-intensive abilities such as math and science, and can also improve agentic capabilities in software-engineering settings. In this work, we study the parallel but less explored agentic capability: general tool use. We present MidTool, an open corpus construction pipeline for agentic tool-use mid-training that combines large-scale web, PDF, and code data with synthesized supervision from real-world tool APIs, MCP skills, and document-grounded workflows. MidTool is designed to teach models how to recognize tool affordances, ground arguments from context, compose tool call workflow, and recover from incomplete information. We mid-train Qwen3-4B-Base and Qwen3-8B-Base on MidTool-Mix, and then apply follow-up post-training with both supervised fine-tuning and reinforcement learning. Compared with baselines, MidTool-Mix consistently improves downstream performance under both SFT and RL on BFCL, tau2-Bench, and MCP Universe. These results suggest that general tool use, like other important LLM capabilities, benefits from dedicated mid-training rather than being left entirely to post-training.

Whether a language model has improved itself is increasingly judged not by mean accuracy but by which individual problems it gains and loses. Tracking these transitions means differencing two noisy estimates, leaving them vulnerable to measurement artifacts. Auditing three rounds of rank-$32$ LoRA self-training on Qwen3-8B against a frozen control pushed through the identical pipeline, we identify seven measurement failures, each of which inverts a reported finding when its control is absent. Several are standard practice. A ledger built on a single greedy decode manufactures capability changes on an untrained model, largely an artifact of inference batching; the expansion statistic separating acquisition from sharpening assigns that same model a rate of $0.280$. The natural threshold repair does not survive replication: estimated across the frozen comparisons such a design already contains, its null stays non-zero. We replace it with a per-problem exact test against a pooled baseline under false-discovery-rate control, which detects nothing on any held-out replicate and is unchanged under the multiple-testing rule, error rate and pool size. Applied to a ladder of arms matched in stream, volume and evaluation, the audit finds that external distillation improves problems the base model rarely reaches while three forms of self-training do not; a regression rejects this asymmetry as a by-product of distillation's larger overall gain ($p < 10^{-8}$). On the far smaller set of problems the base model never reaches, the evidence is inconclusive, while self-training corrupts problems solved at baseline at rates well above the measured floor. Transition-level auditing therefore requires a separately measured null for every statistic it reports: nulls that cost no new experiments, built from baseline replicates a multi-arm study already owns, though not from as few as most possess.

Large language models often fail to answer questions about a bounded document collection when the source documents are not retrieved at inference time. We study this setting as document knowledge internalization: converting a fixed corpus into usable parametric knowledge for retrieval-free question answering. We propose IAR (Inject, Align, and Recover), a three-stage post-training framework that separates structured document knowledge injection, QA behavior alignment, and general ability recovery. Unlike conventional continued pretraining, Inject converts source documents into continuation, rewrite, and instruction-conditioned reconstruction objectives. Align then adapts the injected model with answer-only QA supervision, while Recover merges the domain-adapted model with the base instruction model to recover general capabilities. Across Common Corpus (CC) and CCI, and across Llama, Phi, Qwen, and SmolLM model families, IAR improves the domain-primary domain-general frontier for retrieval-free document internalization. In the main comparison, IAR improves over Vanilla SFT on all four reported metrics in 7 of 8 dataset-model settings, with average gains of 3.6 percentage points in domain QA accuracy and 12.1 percentage points in mean general performance across IFEval, MMLU, and MSBench. Extended CC baselines show that LoRA and FAPM can win individual general metrics, but among methods that also reach leading or near-leading domain internalization, IAR retains one of the strongest general profiles.

Large language model (LLM) agents can induce skills from completed tasks and reuse them later to grow more capable with experience. In practice, induced skills may transfer unreliably and can even harm the agent that retrieves them. When agent-induced skills transfer reliably across tasks remains an open question. We conduct a comprehensive and controlled study of how the way skills are induced shapes their transfer across tasks. Specifically, we compare task-level with subtask-level skill induction and text with code skill formats, the two axes along which existing methods differ. Task-level skills mostly reduce the agent's performance below its no-memory baseline while subtask-level skills raise it above on average, and text skills transfer better than code skills. To further understand our findings, we examine two complementary properties of the induced skills: specificity, which measures how closely a skill matches real tasks, and abstractness, which measures how evenly its relevance spreads across tasks. Neither property alone predicts task success, but their combined effect does, which we propose as a skill utility score. The score correlates consistently with task success when skills are transferred, and subtask-level and text skills score higher. Computing skill utility only needs the skills and task descriptions but not any task execution, so our score serves as a practical diagnostic of a skill memory before any new task runs.

The rapid proliferation of memecoins on blockchain platforms has increased the risk of fraudulent activities, particularly rug pulls. While previous studies have focused on Ethereum-based tokens, this paper shifts the spotlight to Solana, the leading blockchain for memecoins by trading volume and token count. Unlike Ethereum, where rug pulls often exploit smart contract backdoors, Solana memecoin rug pulls are predominantly driven by liquidity manipulation and social dynamics. This research pioneers large-scale rug pull early detection in the Solana ecosystem by assembling a dataset of 6.4 million tokens over 7 months. Market analysis reveals that a vast majority of these memecoins exhibit rug pull characteristics within one hour of launch, highlighting the urgency of short-horizon prediction. Despite the absence of code-level features, we demonstrate that classic machine learning models, particularly Gradient Boosting (XGBoost), achieve robust performance in detecting potential rug pulls using only the first 5 minutes of trading data. Furthermore, we evaluate cross-platform generalization between PumpFun and Raydium, revealing that multi-source data fusion significantly mitigates domain shift and improves detection reliability. This study advances the understanding of DeFi fraud on high-throughput chains and provides a practical framework for protecting investors.

Reasoning language models trained with reinforcement learning typically operate under a fixed token budget rather than an explicitly adaptive one, which can lead to over-computation on easy problems and insufficient computation on difficult ones. We study whether a model can learn to allocate its own reasoning effort by choosing, as the first token of its response, one of three modes: \textsc{NoThink} (answer as quickly as possible), \textsc{Short} (brief reasoning), or \textsc{Long} (extended reasoning). The choice is learned inside Group Relative Policy Optimization (GRPO) with no separate router, through a shaped reward that makes each mode worthwhile at a different response length, together with hard per-mode token caps that keep the modes distinct. On a 1.5B distilled model trained on MATH, the three modes emerge without collapsing to a single choice, and the brief modes end up more accurate than \textsc{Long}, which shows that the router sorts problems by difficulty rather than at random. Averaged over three seeds, the resulting policy stays close to the base model's accuracy on the held-out MATH500 ($0.782$ vs.\ $0.796$) while cutting the mean response length from $4{,}796$ to $2{,}811$ tokens (a $41\%$ reduction). Interestingly, it also transfers to other benchmarks without retraining, with the largest savings where problems are easier, with for instance 76\% token reduction on GSM8K and at higher accuracy than the baselines at similar response length. In short, we build a reasoning model that adaptively chooses how much to reason for each problem.

X-band SAR satellites (8-12 GHz) play a critical role in disaster response, environmental monitoring, and military intelligence. Yet, they lack robust physical-layer authentication (PLA), a security layer orthogonal to cryptographic solutions. Existing PLA systems, typically based on radio-frequency fingerprinting, are often limited to sub-6 GHz frequencies and rely on classical deep learning. However, this approach underfits the IQ phase nonlinearities that distinguish satellite hardware. In this paper, we present QUASAR, to the best of our knowledge the first quantum-classical hybrid architecture that fuses a CNN spectrogram encoder with a variational quantum circuit (VQC) to provide PLA to X-band SAR signals. Our solution enjoys two distinctive features: (i) it is markedly more data-efficient than classical machine learning, requiring only 10% of the training data to match the accuracy of classical baselines -- data collection being notoriously the most time-consuming phase of PLA; and, (ii) at an equal data budget, it improves classification accuracy over those baselines. In detail, we test our solution under three adversarial scenarios: replay, crafted-IQ injection, and space-borne spoofing. QUASAR rejects spoofed transmissions in 89.7%, 94.1%, and 81.3% of attempts, respectively, establishing the first quantum-enhanced physical-layer classifier for satellite constellations. The fully detailed framework and the supporting results, other than being interesting on their own, show a novel research avenue for physical-layer authentication.

Large Language Models (LLMs) increasingly require selective removal of harmful or sensitive knowledge, called unlearning, yet existing methods and benchmarks fail to evaluate this capability completely. Current approaches rely on disjoint forget and retain sets composed of independent facts, and measure success using simple and direct factual recall. This framing fails to capture a key requirement of unlearning, namely the ability to eliminate harmful behaviors while preserving benign and beneficial knowledge. We argue that effective unlearning must operate at the level of concepts, ensuring complete removal of unsafe applications while maintaining their correct and useful usage, thereby achieving conceptually meaningful and complete unlearning. To better evaluate unlearning techniques from such a practical viewpoint, we introduce the notion of dual-use concepts: concepts that can be used in both harmful and benign contexts. Building on these concepts, we construct a benchmark called ConceptGuard where forget and retain sets are explicitly complementary in concept usage. Our benchmark uniquely enables unlearning to be explored and gauged at the level of concepts, instead of sparse facts, and evaluation is intent-sensitive with the goal of maximizing contextual separation to promote safer behavior. We demonstrate that current unlearning techniques perform poorly under this setting, showing weak contextual separation alongside poor performance in ROUGE and concept-level metrics. Our results reveal strong forgetting-utility trade-offs, limited gains in contextual sensitivity, and poor consistency in concept-level control across methods, and provide ideas for unlearning approaches that better align with real-world safety requirements. Our dataset is publicly available.

Small language models are usually built like large ones and then squeezed onto a CPU afterwards. We did the opposite: we fixed the target first, one user, one token at a time, 4-bit weights, ordinary CPU, and chose the architecture to suit it. The result keeps full attention in only 6 of its 18 blocks. The other 12 use short convolutions whose memory is two timesteps wide no matter how long the conversation gets, so two thirds of the network never re-reads a growing cache. Trained from scratch on 59.9B tokens, the model scores 47.31 on a five-task benchmark against a bar of 42.20 that was fixed before training began. It beats GPT-2 124M, Pythia-160M, OPT-125M and GPT-neo-125M, all trained on three to six times more data, and exceeds MobileLLM-125M's published score despite that model seeing a trillion tokens. Validation bits-per-byte is 0.8685. To check the architecture rather than the training recipe, we trained a conventional all-attention model of the same size on the same data, and wrote down the winning condition before scoring either. The hybrid won the chosen quality metric by 0.81%, matched it on downstream tasks, produced a 6.3% smaller 4-bit file, and decoded 1.76x faster at 2048 tokens of context, 2.08x against an external model of similar size. In every measurement the speed advantage is near zero at an empty context and grows with length, which is what the mechanism predicts and what a merely leaner model would not show. A simple bandwidth calculation predicts only 1.17x, so memory volume alone does not explain the gap. We also report what did not work: an unmitigated 4-bit quality cost, roughly half the convolution channels ending up inert and impossible to remove, and a vocabulary larger than this model size warrants.

Legal work, with its heavy reliance on processing large amounts of text, is often considered one of the domains most exposed to the use of LLMs. Contract ``scrubbing,'' the final review of transactional agreements for errors and inconsistencies, is a particularly suitable task for automation, because it is routine, painstaking work requiring detailed attention to long documents. Scrubbing also seems to align naturally with the general capabilities expected of frontier LLMs around long-context reasoning, consistency checking, and named entity recognition (NER). Despite the economic value and potential for automation, no formal evaluations of LLMs performing contract scrubbing have been conducted. We introduce ContractScrub, the first benchmark designed to evaluate contract scrubbing capabilities, comprising contracts hand-crafted by experienced lawyers over diverse error categories such as misuse of defined terms, incorrect references, and inconsistent language. Frontier models perform surprisingly poorly with only one model reaching 0.75 macro average recall despite strong performance on seemingly related general benchmarks, demonstrating the practical limits of current models and the importance of narrowly targeted, domain-specific benchmarks for measuring real-world impact.

Memory has become a key component of large language models, enabling them to retain information and learn from long-term interactions. However, existing memory benchmarks mainly evaluate whether information is correctly extracted, stored, and retrieved, while largely overlooking how retrieved memories reshape model reasoning and affect performance on the current task. We identify memory-induced cognitive traps: even faithfully recorded and semantically relevant memories can distort model reasoning or beliefs and degrade current task performance. To systematically evaluate these failure modes, we introduce MemTrapBench, which covers two forms of cognitive traps: Reasoning Fixation and Belief Distortion. Experiments across two model families and five representative memory frameworks show that MemTrapBench is challenging: all evaluated memory strategies underperform the no-memory setting, with even the strongest methods suffering drops of more than 10%. To mitigate these cognitive traps, we propose AdaptiveMem, a simple yet effective inference-time method that instructs LLMs to avoid memory traps. AdaptiveMem mitigates cognitive traps on MemTrapBench while preserving or improving performance on standard memory benchmarks across diverse memory frameworks.

We present a novel approach to efficient LLM agent harness optimization through adaptive validation task selection. Harness optimization iteratively rewrites the harness code based on validation performance, enabling substantial performance gains without updating the underlying model weights. Existing approaches, however, evaluate a fixed validation set in full at every iteration, incurring substantial evaluation costs even on tasks that become less discriminative as the harness evolves. We propose $\textbf{Task-CoEvolve}$, which co-evolves the validation tasks with the harness by addressing two challenges: selecting informative tasks and estimating full-set performance from partial evaluations. Task-CoEvolve builds on the observation that tasks on which candidate harnesses disagree are more informative for distinguishing among them than tasks that are consistently solved or failed. It uses variance-weighted sampling based on past outcomes to focus evaluation on tasks near the agent's capability frontier, with the sampling distribution adapting as the harness evolves. It then estimates full-set scores from the sampled tasks by accounting for their sampling probabilities, enabling consistent comparisons across iterations despite evaluating different subsets. Experiments on online text classification and Terminal-Bench 2.1 show that Task-CoEvolve consistently outperforms fixed-subset baselines and matches the final performance of full-set search while reducing the number of evaluations during optimization by 80%. Code will be released at https://github.com/Agent4Science-UTokyo/Task-CoEvolve.

Accounting for information flow on the path space of trajectories of a nonnegative martingale yields exact variational identities for it, even at arbitrary random times. This recovers the widely used classical concentration inequalities, from Ville to PAC-Bayes, and measures what each one discards. The tail a bound controls is itself a relative entropy, resolved by the chain rule into per-step conditional divergences. The discarded slack has an exact form in each of three geometries: a Gibbs tilt for the Azuma-Hoeffding and PAC-Bayes bounds, the crossing itself for Ville's and for pooled tests, and a dominating certificate for the $L^p$ maximal bound. That certificate's optional-stopping deficit resolves per step into Bregman divergences of the running maximum. On a path-time space, the same identity gains one factor that prices anticipation: an arbitrary random time carries an e-process ``peeking penalty.'' The partition function can be read as a coalescent--a prefix-sharing probability of independent copies--and geometric mixtures of test martingales gain a pooling benefit for multi-model safe testing.

Deep neural networks are often overconfident, assigning high confidence even to incorrect predictions. Consequently, users lack a reliable signal for deciding when a prediction can be trusted. Post-hoc confidence estimation addresses this by training a lightweight auxiliary head over a frozen classifier. Existing targets, however, suffer from inherent ambiguity: they assign overlapping confidence values to correct and incorrect predictions, while errors near the decision boundary receive confidence scores indistinguishable from correct predictions. In this work, we propose $TCP_α$, a novel confidence target that resolves these limitations by introducing a margin-controlled penalty for misclassified samples. We prove that $TCP_α$ guarantees complete separation between the target values of correct and incorrect predictions, with a separation margin that is independent of the number of classes and increases monotonically with the penalty parameter. Since accurate classifiers naturally produce very few errors, learning these targets results in a severely imbalanced regression problem. We therefore present a systematic study of training strategies for learning under this imbalance and identify an effective training configuration through extensive ablation studies. We evaluate the proposed approach on rāga identification, investigate its robustness under domain shift, and further validate it on frame-wise ornamentation detection without modifying the selected configuration. Across all settings, $TCP_α$ consistently outperforms existing confidence targets for failure prediction. Rejecting only the least-confident 8\% of predictions improves the base model's macro-F1 from 0.89 to 0.98, while fine-tuning the confidence head with only 5\% labeled samples from a new corpus effectively restores performance under domain shift.

Despite their growing importance for contact-free radio frequency (RF) based healthcare monitoring, different radio technologies such as frequency-modulated continuous wave (FMCW) radar, impulse radio ultra-wideband (IR-UWB), and Wi-Fi sensing are rarely compared under identical deployment conditions, as existing studies typically differ in hardware, datasets, and evaluation methodologies. In addition, the performance of ceiling-mounted radars, despite their practical deployment and cost advantages in healthcare environments, remain underexplored. Therefore, this paper presents a controlled comparison and analysis of ceiling-mounted FMCW, IR-UWB, and Wi-Fi sensing using synchronized recordings from 20 participants across six room layouts. All technologies are evaluated with the same convolutional neural network (CNN) on both a fine-grained 10-class human activity recognition (HAR) task and a coarse 4-class sleep monitoring task. IR-UWB achieves the highest cross-subject activity recognition performance (89.0% macro F1), while FMCW generalizes best to unseen room layouts (83.8% macro F1). For sleep monitoring, all technologies exceed 92% macro F1 in unseen environments. The results reveal a fundamental trade-off between recognition performance and environmental robustness, which can be explained through differences in range resolution, antenna diversity, Doppler resolution, and spatial information retention. These findings provide practical guidelines for the design of healthcare-oriented RF sensing systems.

Predictive models over structured electronic health records (EHRs) remain central to machine learning for healthcare, but few have jointly emphasized quantitative laboratory information and interpretability with respect to input medical events. We present BERT-LER, a BERT-style model for coded EHR timelines pretrained and fine-tuned from a de-identified EHR dataset of 75 million patients, that encodes laboratory test results as discrete tokens while retaining graded information through percentile-based binning, paired with Integrated Gradients for token-level attributions grounded in the input EHR sequence. We benchmark our approach on the public EHRShot benchmark suite and on an asthma severity progression study based on real-world data. This addresses a methodological gap in EHR foundation-style modeling by unifying laboratory value representation and explainability in a single framework, while assessing whether both predictive performance and explanations generalize beyond standard clinical prediction tasks. Across EHRShot and asthma tasks, BERT-LER achieves predictive performance that is competitive with, and on laboratory-related tasks often exceeds, publicly available benchmark models, and provides attributions that align with clinically known risk factors. Our architecture and explainability approach can be applied to many therapeutic areas and prediction tasks using language models trained on structured EHRs.

Sparse pursuit after dictionary learning can yield a precise atom support even when its physical interpretation is not justified by the calibration data, especially for highly coherent dictionaries where alternative calibration-compatible dictionaries may assign different physical meanings to the same selected support. We develop resolution-aware physical-support inference that jointly accounts for uncertainty in the learned dictionary and in the representation of a deployment signal. Our cross-dictionary confidence correspondence retains calibration-compatible dictionaries and deployment-compatible sparse representations, then projects the surviving explanations onto physical-support space. For local coherent-atom classes with separation scale s, once the deployment data resolve the coherent-block explanation and its atom support, the minimax physical resolution from N calibration signals satisfies $δ_{\mathrm{opt}}(N,s)\asymp\min\{s,\frac{1}{\sqrt{N}s^2}\}$, with relative resolution governed by the orientation-information scale $Ns^6$. Deployment replication improves physical localization only when orientation changes cannot be absorbed by adjusting the active coefficients. For computation, we introduce active endpoint bracketing (AEB), an adaptive finite-bank procedure that evaluates only candidates that can still affect the physical report and otherwise safely coarsens or abstains. Finite-bank experiments, including a four-region synthetic application, show that a point-valued plug-in selector can be physically overprecise, whereas AEB avoids unsupported refinement with fewer candidate evaluations.

The causal dynamics of sleep-disordered breathing are complex and vary across patient populations, hindering the development of targeted interventions. We learn dynamic causal graphs of sleep-disordered breathing from Home Sleep Apnea Test (HSAT) recordings, revealing systematic differences in causal structure across sex and age subcohorts. We do so using the PCMCI+ algorithm on windowed fractional variables derived from 105 HSAT recordings, exploiting domain knowledge via edge blacklisting and employing bootstrap aggregation to address small subcohort sizes. The learned graphs show that temporal self-dependencies and the apnea-desaturation relationship persist across all cohorts, while other relationships vary substantially.

Semantic caches reuse an LLM response when the incoming query embedding lies near a cached query, but proposed eviction policies have rarely been compared under one protocol. Using CLEVER, we evaluate FIFO, LRU, LFU, ARC, GDSF, a single-pass streaming adaptation of SISO, and a semantic-redundancy policy across three ordered, deduplicated query corpora, three cache capacities, and two encoders. No evaluated policy improves on LFU by more than 0.041 percentage points in any of the eighteen settings. Replacement is not irrelevant: FIFO and streaming SISO trail LFU by as much as 8.67 and 8.55 points, respectively, at tight capacity. We explain the missing upside with a conditional packing result. Under exact lookup and insert-on-miss, a newly inserted entry cannot have a resident neighbor within the hit radius, so a geometry-aware eviction rule receives little new redundancy signal. A separate audit exposes a larger problem with the evaluated operating point. At MiniLM's median nearest-neighbor threshold, only 2.1-3.9% of sampled LMSYS and QQP hits are judged answer-substitutable, reducing raw hit rates of 51-60% to quality-adjusted rates of 1.1-2.2%. The cross-encoder study further shows that thresholds do not transfer between embedding models. LFU is the strongest simple default in this protocol; deployment decisions should first establish answer validity and then test sub-point policy differences with exact search.

Decision tree-based models are widely used in machine learning due to their interpretability and strong empirical performance. However, training decision trees can be computationally expensive, particularly for large and high-dimensional datasets, largely due to the exhaustive search over candidate splits at each node. To improve computational efficiency, we propose Data-Informed Centroid Splitting (DICS), a clustering-based framework that constructs a compact and informative set of candidate splits using data-driven priors. By incorporating class-aware structure, DICS significantly reduces the split search space for classification tasks while preserving predictive performance. We further provide theoretical analysis showing that under the stated assumptions, DICS does not degrade the performance of classification trees compared to exhaustive split search. DICS can be incorporated into classification trees, random forests, and gradient-boosting models. Extensive experiments demonstrate that DICS achieves comparable accuracy while substantially reducing training time across synthetic and benchmark datasets, highlighting the benefit of integrating data-informed priors into split selection for scalable classification tree learning.

This paper develops a general transfer learning framework for nonparametric regression with data consisting of multiple groups. Under the assumption that groups share a common structure along with group-specific deviations in additive form, the proposed method employs a two-stage offset learning procedure: the first stage pools data from all groups to estimate an overall mean function, and the second stage estimates offsets for each group, yielding final group-level estimators through additive combination. Upper bounds on the $\mathcal L_2$ error are established for the proposed framework, covering a broad class of nonparametric estimators under mild complexity and noise conditions. When instantiated with deep ReLU networks, explicit convergence rates are derived under hierarchical composition models, demonstrating the ability to overcome the curse of dimensionality. Conditions that enable positive transfer with faster rates are considered, including learning with simpler functions and data augmentation through pooling samples across groups. Various simulations and real-data experiments further validate the effectiveness of the proposed method.

The worldwide network of gravitational-wave detectors have detected more than 350 binary coalescence events till date. Future third-generation detectors, like Einstein telescope, are expected to detect orders-of-magnitude more signals from sources with more complicated characteristics, including eccentric orbits and high-mass ratio binaries. It is well-established that the computational cost of parameter estimation for signals from these kinds of sources will be extremely high. In particular, the process could be sped-up if generating theoretical waveform predictions, used for likelihood calculation becomes faster. Recently, various machine-learning techniques has been proposed to this end. In this work, we propose a two-stage deterministic conditional-autoencoder model for generating four-parameter SEOBNRv4 waveforms. The first-stage of the model generates amplitude and phase series of the waveform, while the second-stage calibrates the residual error in the predictions. Our model achieves a median mismatch of around $10^{-2}$ with the target polarization waveforms, while the calibrated amplitude/phase series achieve $10^{-6}$ level cosine distance error. We then propose a waveform conditioning step to enable use of these surrogate waveforms for downstream parameter estimation tasks. Finally, we perform extensive parameter estimation tests, with ML and EOB waveform injections and try to recover posterior estimates for the source parameters. We find that when ML waveforms are used to recover EOB target parameter estimates, the inferred posterior have some systematic bias. This inherent bias can be estimated and corrected for, and then importance reweighting of posterior samples can enable use of low-accuracy surrogate waveforms at low SNRs.